Regulation and substrate identification of Parkinsons disease causative Leucine-rich Repeat Kinase 2 (LRRK2)

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/566743

Funding Status
Closed

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Funded Activity Summary

Parkinson's disease afflicts 100,000 Australians. Mutations in the recently identified enzyme Leucine-rich Repeat Kinase-2 are a common cause of Parkinson's disease. This project will use biochemical methods to understand how this brain enzyme causes disease by investigating its enzymology, modes of regulation, and target substrates that it modifies by addition of phosphate groups. Characterization of this enzyme will facilitate design of inhibitors to slow the course of Parkinson's disease.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $699,456.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical infection agents (incl. prions)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Enzyme | Movement disorder | Neuronal death | Parkinson's disease | Protein kinases | aging | dementia | neurodegeneration | neurodegenerative diseases

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