The Role of Pulmonary Macrophages in the Pathogenesis of an Acute Exacerbation of Chronic Asthma

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/568616

Funding Status
Closed

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Funded Activity Summary

We will examine the role of lung defence cells, known as macrophages, in triggering the inflammation of acute severe asthma. The experimental work will use unique mouse models of mild chronic asthma and of an acute exacerbation of the illness, which have been developed in our laboratories. We will study the mechanisms of activation of the asthmatic response and assess whether treatment with drugs that suppress the function of macrophages can help to control steroid-resistant exacerbations.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $495,710.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Respiratory Diseases

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

acute exacerbation of chronic asthma | airway inflammation | alveolar macrophages | asthma | corticosteroids | steroid resistance of acute severe asthma

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