CD4+ T-cells in HIV - regulator or target of viral infection: a modelling approach

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/568823

Funding Status
Closed

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Funded Activity Summary

T-cell loss due to HIV infection causes immunodeficiency. Since virus grows faster if more T-cells are available and preferentially infects dividing cells, we want to understand how replacement, division and death of uninfected T-cells affect the progress of HIV infection and T-cell recovery during drug therapy. The results of our study will lead to a better understanding of HIV disease, and may assist in the development of novel treatment regimes optimising T-cell numbers during infection.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $319,740.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Applied immunology (incl. antibody engineering xenotransplantation and t-cell therapies)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

HIV infection | HIV pathogenesis | HIV-AIDS | T lymphocytes | T-cell depletion | anti-retroviral drug therapy | cell proliferation | gut immunity | homeostasis | leukocyte trafficking

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