Definition of the role of senescence in tumour-associated endothelial cells.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/570764

Funding Status
Closed

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Funded Activity Summary

'Cellular senescence' is a mechanism to stop cells growing, and it may protect against tumour growth. However, it may also induce changes in cells leading to 'pro-tumour' effects. We have identified a gene - which we have called SEN1 - which induces senescence in the blood vessels of tumours. This gene may cause alterations in the blood supply to the tumour allowing it to grow and to resist chemotherapy. Understanding this gene may allow us to treat cancer by shutting off its blood supply.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2011

Funding Scheme: NHMRC Project Grants

Funding Amount: $583,081.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Oncology And Carcinogenesis

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Angiogenesis | Cancer | Cellular senescence | Chemo--radio- therapy | Endothelial cells | Metastasis | Tumour | Tumour Biology | Tumour growth and metastasis | Vascular biology

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