Does oxidation of lipoproteins by thiocyanate-derived oxidants produced by myeloperoxidase contribute to atherosclerosis

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/570829

Funding Status
Closed

Does something not look right? The information on this page has been harvested from data sources that may not be up to date. We continue to work with information providers to improve coverage and quality. To report an issue, use the .

Funded Activity Summary

Considerable evidence links the heme enzyme myeloperoxidase with atherosclerosis (hardening of the arteries), a disease that kills approximately 40% of Australians, and particularly people who smoke. The reasons for the elevated risk in smokers is not fully understood, though it is known that they have elevated thiocyanate levels - a major substrate for myeloperoxidase. The role of myeloperoxidase and thiocyanate in lipoprotein damage in atherosclerosis will be addressed in this project.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $357,930.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Nutrigenomics and personalised nutrition

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Atherosclerosis | Cardiovascular disease | Inflammation | Lipoprotein | Myeloperoxidase | Oxidative stress | Prevention of coronary heart disease

Related Links

ACN 633 798 857