Mechanisms of action of the antigen presenting cells that impair lymphoma-specific cytotoxic T lymphocytes

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/575540

Funding Status
Closed

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Funded Activity Summary

Our immune systems are continually fighting cancer. However, the cancer cells occasionally acquire mutations that enable them to subvert the immune system. Usually they do this by hiding under the appearance of normal tissue, but sometimes they activate the very mechanisms that are in place to shut-down immune responses when these are no longer necessary. The goal of this proposal is to identify such mechanisms and find ways of bypassing them, thus restoring anti-tumour activity in patients.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2011

Funding Scheme: NHMRC Project Grants

Funding Amount: $295,983.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Diagnostic radiography

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Activation Induced T Cell Death-Apoptosis | Cytotoxic T Lymphocyte exhaustion and suppression | Dendritic cells and myeloid suppressor cells | Immunotherapy and Immunoevasion | Mouse model of Leukemia-Lymphoma | T cell immunotherapy | immune regulation | tumour Immunotherapy

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