Regulation of B lymphocyte survival and tumourigenesis by the TRAF2-TRAF3-cIAP signaling complex

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/596822

Funding Status
Closed

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Funded Activity Summary

A major contributing factor in the development of cancer is the loss of the normal controls that regulate cell survival. We have identified a group of proteins that control the survival of B cells, the white blood cells responsible for producing the antibodies that fight infections. In this project we will investigate the mechanisms by which these proteins function and how inactivation of their functions can lead to multiple myeloma, an aggressive cancer of antibody producing cells.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $439,395.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Haematological Tumours

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Cancer cell biology | Cell Development, Proliferation and Death | Cellular immunology | Immune response | Lymphoma | Myeloma | Signal transduction

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