To determine the means by which plasminogen activators modulate integrity of the blood brain barrier

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/606658

Funding Status
Closed

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Funded Activity Summary

Tissue-type plasminogen activator (t-PA) is used clinically to remove blood clots. However, t-PA can also cause brain injury and influence the blood brain barrier (BBB) which has implications for the treatment of patients with ischaemic stroke. This project will use in vitro and in vivo models to understand the mechanism by which t-PA modulates the BBB. A novel tPA variant will also be created that ultimately may be of benefit for patients with ischaemic stroke.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $523,084.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Haematology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

acute ischaemic stroke | fibrinolysis | haematological disorders | improving outcome and safety for thrombolysis in stroke | neuronal cell death | plasminogen | stroke | thrombolysis

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