Interactions between excretory-secretory proteins of the carcinogenic liver fluke and host cells

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/613669

Funding Status
Closed

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Funded Activity Summary

Throughout East Asia, there is a strikingly high prevalence of cholangiocarcinoma (CCA - cancer of the bile ducts) in regions where the human liver fluke is endemic. How the parasite casues cancer is multi-factorial, but one suspected mechanism is via the secretion of parasite proteins that enter bile duct cells and cause them to proliferate. We aim to understand this process and ultimately develop new control strategies to reduce the prevalence or the infection and CCA.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $489,122.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical Parasitology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Opisthochis | PGP3 | Southeast Asia | bile duct cancer | carcinogenesis | chronic helminth infection | endocytosis | excretory-secretory proteins | liver fluke

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