Gene therapy, stress haematopoiesis and the risk of malignancy

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/632657

Funding Status
Closed

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Funded Activity Summary

The immense potential of gene therapy has been confirmed by the successful treatment of immune deficiencies disorders. A key issue that has emerged however is the need to avoid potentially cancer-causing genetic damage to cells undergoing repair. Some of this risk can be linked to the gene repair technology used, but we have identified and propose to investigate another potentially important mechanism involving the unusually high levels of replication imposed on cells during disease correction.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2013

Funding Scheme: NHMRC Project Grants

Funding Amount: $617,354.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Gene and Molecular Therapy

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Bone marrow reconstitution | Cancer biology | Cell growth-differentiation | Cell proliferation | Gene therapy | Lentiviral vector | Lymphocyte differentiation | Oncogenesis | Risk factors

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