Role of dynamin in modes of synaptic vesicle endocytosis

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/633225

Funding Status
Closed

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Funded Activity Summary

Neurons communicate by neurotransmitter release from synaptic vesicles stored in nerve endings. There is a finite vesicle number, so they are recycled (endocytosis) by dynamin. Our aim is to reveal the molecular mechanisms underlying endocytosis to better understand diseases of the synapse like epilepsy. We propose that two forms of the dynamin gene mediate two forms of endocytosis, one of which is activated only under conditions of high neuronal firing, such as occurs during a seizure.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2013

Funding Scheme: NHMRC Project Grants

Funding Amount: $905,985.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Central Nervous System

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Endocytosis | Epilepsy | Molecular neuroscience | Nerve terminals | Nervous system disorders | Neurochemistry | Neurotransmission | New epilepsy treatments | Phosphoproteins | Synaptic transmission

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