The effect of Cytochrome P450 genotype on blood pressure and 20-HETE responses to lifestyle interventions

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/634359

Funding Status
Closed

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Funded Activity Summary

The effectiveness of treatments to reduce heart disease risk can vary enormously between individuals. This is partly due to a persons genetic makeup. Fatty acid metabolites called cytochrome P450 metabolites of arachidonic acid (CYP450-AAM) can act on blood vessels and the kidney to regulate blood pressure. We will study the effect of having a variation in a gene that regulates CYP450-AAM on blood pressure and heart disease risk in combination with a high salt diet or weight reduction.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2013

Funding Scheme: NHMRC Project Grants

Funding Amount: $743,665.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cardiology (incl. Cardiovascular Diseases)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

atherosclerosis | blood pressure | cardiovascular disease | cardiovascular risk | cytochrome P450 arachidonic acid metabolites | diet | hypertension | mass spectrometry | metabolic syndrome

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