A new BTB-ZF family transcription factor required in development and dysregulated in malignant disease

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/637395

Funding Status
Closed

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Funded Activity Summary

We are studying the function and biology of a novel gene that looks like a generegulator. We generated a zebrafish mutant with defective myeloid development, and we found this gene causes the defect. This mutant fish provides a handle on the biological function of the gene in development. This gene has the hallmarks of a transcription factor and we will study how it regulates other genes, and how it may be a target for treatment of several cancers in which expression of this gene is activated.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2013

Funding Scheme: NHMRC Project Grants

Funding Amount: $439,813.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Gene Expression (incl. Microarray and other genome-wide approaches)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

blood diseases | congenital defects | embryonic development | gene regulation | haematopoiesis | leukaemia | myelopoiesis | transcription factor | zebrafish

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